Translocation (8;21) in acute nonlymphocytic leukemia delineated by chromosomal in situ suppression hybridization.

نویسندگان

  • S Popp
  • A Jauch
  • J Y Qiu
  • B Smialek
  • T Cremer
  • R Becher
چکیده

In situ suppression hybridization with recombinant bacteriophage DNA libraries for chromosomes 8 and 21 was performed in two cases of acute nonlymphocytic leukemia, type FAB M2. In both cases, cytogenetic analysis by conventional G-banding revealed t(8;21)(q22;q22). In situ suppression hybridization was able to prove the reciprocal nature of the translocation in both cases by identifying the terminal end of chromosome 21 translocated to the derivative chromosome 8q-.

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عنوان ژورنال:
  • Cancer genetics and cytogenetics

دوره 57 1  شماره 

صفحات  -

تاریخ انتشار 1991